Inference procedures

Quantifying within-sample heterogeneity

Memento uses bootstrap to quantify within-sample heterogeneity of gene expression. You can specify whether to use the raw values to calculate a P-value or fit a Normal distribution to the sampling distribution. We have found that this works particularly well for the mean.

Quantifying between-sample heterogeneity

Hierarchical bootstrap

Under construction

Quasi-maximum likelihood

Under construction